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hSMG-1 inhibitor 11j
CAS No. 1402452-15-6
hSMG-1 inhibitor 11j ( —— )
Catalog No. M28582 CAS No. 1402452-15-6
hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 219 | Get Quote |
|
| 5MG | 372 | Get Quote |
|
| 10MG | 556 | Get Quote |
|
| 25MG | 887 | Get Quote |
|
| 50MG | 1197 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamehSMG-1 inhibitor 11j
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NoteResearch use only, not for human use.
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Brief DescriptionhSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM.
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DescriptionhSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.(In Vitro):hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells. hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation an IC50 = 75 nM .
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1402452-15-6
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Formula Weight566.1
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Molecular FormulaC27H28ClN7O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(C=C1)C2=NC=CC(=C2)C3=NC(=NC=C3)NC4=CC=C(Cl)C(=C4)S(=O)(=O)N(CC)CC)NC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bai ZQ, et al. New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius. Fitoterapia. 2014 Jun;95:194-202.
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