hSMG-1 inhibitor 11j

Research use only, not for human use.

hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM.

hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer.(In Vitro):hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells. hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation an IC50 = 75 nM .

——

PI3K/Akt/mTOR signaling

PI3K

——

——

——

1402452-15-6

566.1

C27H28ClN7O3S

>98% (HPLC)

——

O=C(NC1=CC=C(C=C1)C2=NC=CC(=C2)C3=NC(=NC=C3)NC4=CC=C(Cl)C(=C4)S(=O)(=O)N(CC)CC)NC

——

(-20℃)

With Ice Pack

≥ 2 years